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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Antioxidant and Anti-Inflammatory Activities of Ginger Aqueous and Ethanolic Extracts

    wadmin1By wadmin1October 1, 2012Updated:August 7, 2021No Comments2 Mins Read
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    Sellal A 1, Belattar R 2 , Senator A 1
    1 Laboratory of Biochemistry, Faculty of Natural Sciences and Life, Department of Biochemistry, University Ferhat Abbas. Setif
    2Department of Ecology and Plant Biology University of Constantine. Algeria E-mail: sellalhak@yahoo.fr

    Pharmacognosy Communications,2012,2,4,03-10.
    DOI:10.5530/pc.2012.4.2
    Published: Oct 2012
    Type: Research Article

    ABSTRACT

    In the present study, the activities of ethanolic and aqueous extracts from ginger rhizome were evaluated in vivo using acetic acid induced vascular permeability and xylene induced ear edema by topical application in mice as a model of acute infl ammation. The oral administration of this extracts at dose of 400 mg/kg one hour before the induction of infl ammation showed a highly signifi cant (p ≤ 0.01) anti-infl ammatory effect (compared to control group considered as 100% of infl ammation). The antioxidant effect of the ethanolic extract was also studied in vitro using the DPPH free radical scavenging assay, total antioxidant activity, metal chelating activity and ß-carotene/linoleic acid tests. Where the increased volumes of extract studied taken from a stock solution of a fi xed concentration 1 mg/ml at 25–250 μl in the DPPH free radical scavenging assay, 15 μl in the total antioxidant activity assay and 250 μl in the ß-carotene / linoleic acid test gave a signifi cant (p ≤ 0.01) antioxidant activity. The results obtained showed that this extract has a good scavenger effect towards DPPH radical, and the lipid peroxidation activity in the total antioxidant activity assay and ß-carotene/linoleic acid tests. In Contrast, this extract had no metal chelating effect where the volumes of 25–200 μl gave a non signifi cant differences.

    Key words: Infl ammation , oxidation , free radicals , ginger , Zingiber offi cinale , DPPH.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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