Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Effect of Hordeum vulgare Linn. Seeds on glycolic acid induced urolithiasis in rats

    wadmin1By wadmin1April 1, 2012Updated:August 11, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Jignesh G. Shah1, Dr. Bharat G. Patel2, Sandip B. Patel1, Ravindra Patel1
    1Department of Pharmacology, Indukaka Ipcowala College of Pharmacy, New Vallabh vidyanagar, Anand, Gujarat, India. 2Institute of Science & Technology for Advanced studies & Research, Vallabh vidyanagar, Anand, Gujarat, India.

    Pharmacognosy Communications,2012,2,2,34-39
    DOI: 10.5530/pc.2012.2.5
    Published:April 2012
    Type: Research Article

    ABSTRACT

    Objective: To evaluate its anti-urolithic potential, the ethanolic extract of seeds of Hordeum vulgare was tested in an animal model of urolithiasis. Materials and Methods: Urolithiasis was induced by the addition of 3% glycolic acid to the normal diet of Wistar albino rats for a period of 42 days. Group I served as a normal control. Group II served as urolithiasis control. Group III, IV and V were treated with ethanolic extract of Hordeum vulgare (EHV) at 100, 250 and 500 mg/kg respectively. Group VI was treated with Cystone as a standard drug. The effects of EHV on various biochemical parameters were studied in urolithitic rats. Results: Glycolic acid induced hyperoxaluria in urolithiatic rats. And, there were significant elevated urine output, kidney weight loss and some renal injury markers in glycolic acid induced rats. In vivo antioxidant parameters including lipid peroxidation (MDA), superoxide dismutase (SOD) and catalase (CAT) were also determined. oral administration of EHV 100, 250 and 500 inhibited CaOx crystal disposition in renal tubules and protected against associated changes in polyurea and kidney weight loss. EHV significantly maintained the urinary excretion of the calcium, phosphate, uric acid, urea, and oxalate and increased the excretion of citrate as compared to glycolic acid control animals. The increased deposition of stone forming constituents in the kidneys of calculogenic rats were significantly lowered by treatment with EHV. The extract also induced a significant decrease in MDA which increased in urolithiatic control rats. The extract also significantly increased SOD and CAT in urolithiatic rats which were markedly decreased in glycolic acid induced urolithiasis in rats. Conclusion: This study demonstrates the anti-urolithic activity of Hordeum vulgare seeds and rationalizes their medicinal use for the treatment of urolithiasis.

    Key words: glycolic acid; Hordeum vulgare; urolithiasis.

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up