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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Letter

    Evaluation of radioprotective properties of Curcuma longa rhizome extract: A cytogenetic analysis in cancer

    wadmin1By wadmin1April 1, 2012Updated:August 11, 2021No Comments2 Mins Read
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    Gyanendra Singh4, Swapnil Sharma, Naveen Choudhary3, Sachdev Yadav1, Rajani Chauhan1, and Jaya Dwivedi2

    1Deptt. of Pharmacy, Banasthali University-304022, Rajasthan, India.

    2Deptt. of Chemistry, Banasthali University,-304022, Rajasthan, India.

    3Mandsaur institute of pharmacy, Mandsaur Rajasthan, India. 4Apex institute of pharmacy, sitapura, Jaipur, Rajasthan, India.

    Pharmacognosy Communications,2012,2,2,44-49
    DOI: 10.5530/pc.2012.2.7
    Published:April 2012
    Type: Research Article

    ABSTRACT

    This is aimed to examine radio protective effect of Curcuma longa rhizome extract (CLE) on radiation induced chromosomal aberrations in cancer treatment. The 50% hydroalcoholic extract was used to treat blood sample (taken from a healthy volunteer). In-vitro cytogenic analysis was performed by arresting metaphase using colchicine. The chromosomal aberrations were observed using light microscopye. For evaluation of the radioprotective role of CLE the abnormal metaphase aberrations were analyzed and their percentage was calculated. Pre-treatment and post treatment with Curcuma longa extract (CLE) at 200 mg/bodyweight mg/body weight, resulted in a significant reduction in the abnormal metaphases, as well as in the different types of aberration. It was concluded that Curcuma longa extract (CLE), when given prior to radiotherapy lead to a decrease in all types of chromosomal aberrations. CLE may therefore have applications to as an adjuvant to radiotherapy in cancer treatment due to its radioprotective potential.

    Key Words: Curcuma longa, turmeric, cancer, radioprotective effect, metaphase, cytogenic analysis.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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