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Hepatoprotective activity of Santolina chamaecyparissus Linn against D-Galactosamine Induced Hepatotoxicity in Rats

Dhanabal SP*1, Rahul Jain1, Priyanka Dwarampudi L1, Muruganantham N1, Raghu PS2

1Department of Phytopharmacy and Phytomedicine (TIFAC CORE HD), JSS College of Pharmacy, Rocklands, Ooty, Tamilnadu, India – 643001.

2Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Rocklands, Ooty, Tamilnadu, India – 643001.

Pharmacognosy Communications,2012,2,2,67-70
DOI: 10.5530/pc.2012.2.10
Published:April 2012
Type: Research Article

ABSTRACT

Background: Santolina chamaecyparissus Linn. is used traditionally in Ayurvedic system of medicine in India for the treatment of liver diseases, and as a liver tonic. Methods: The hydroalcoholic extract of Santolina chamaecyparissus Linn. whole plant was tested for its hepatoprotective effect against D-galactosamine induced hepatic damage in rats at a dose of 250°mg/kg. Results: The substantially elevated levels of aspartate amino transferase (ASAT), alanine amino transferase (ALAT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), total cholesterol (TC), triglycerides (TGL), total protein (TP) and albumin (TA) were restored significantly (p<0.001) by the extract The hepatoprotective effect was comparable to that of standard silymarin. Results of histopathological studies supported these findings. Conclusion: It can be concluded from the present study that, the hydroalcoholic extract of Santolina chamaecyparissus Linn. has appreciable hepatoprotective potential.

KeyWords: D-galactosamine, flavanoids, hepatoprotective effect, histopathological studies, Santolina chamaecyparissus.

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