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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    In-vitro Prevention of Cataract by Ginseng on Isolated Goat Eye Lens

    wadmin1By wadmin1April 1, 2012Updated:August 11, 2021No Comments2 Mins Read
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    Nithya S, Sumadhuri S, Anbu J, Sumithra M
    Department of Pharmacology, School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai 600117, India.

    Pharmacognosy Communications,2012,2,2,40-43
    DOI: 10.5530/pc.2012.2.6
    Published:April 2012
    Type: Research Article

    ABSTRACT

    Objective: The aim of the present work was to evaluate the in vitro effect of ginseng on cataract induced by glucose. Materials and Methods: Goat eye lenses were divided into four groups. Group I lenses were incubated in artificial aqueous humor with glucose concentration 5.5 mM (normal control). Group II lenses were incubated with glucose concentration 55 mM (toxic control). Group III and IV lenses incubated with glucose concentration 55 mM were incubated along with ginseng 50 and 100mg/ml and subjected to morphological and biochemical evaluation. Results: Group II lenses showed high amounts of malondialdehyde (MDA) soluble and insoluble protein and decreased catalase and glutathione levels., Lenses treated with ginseng showed significant (P < 0.05) reductions in MDA, as well as increased levels of catalase (P < 0.001), glutathione (P < 0.005) and total and soluble protein. Conclusions: Ginseng showed prevention of in vitro glucose induced cataract. Thus the goat lens model could be used for testing of various anticataract agents.

    Key words: Cataract, catalase, in vitro, glutathione, lens, ginseng, Panax ginseng

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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