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    Pharmacognosy Communications
    • Home
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    Pharmacognosy Communications
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    Research Article

    Tetrahydrocurcumin: Beneficial Effects on HMG-CoA Reductase enzyme and Lipoprotein Lipase Enzymes in High-fat diet-induced Hypercholesteremia Rabbits

    wadmin1By wadmin1April 1, 2012Updated:August 11, 2021No Comments2 Mins Read
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    Kalavarasariel Gopinathanpillai Prasanth1*, Eluri Kalpana1, Balasubramaniam Dineshkumar2, Elumalai Monogaran3, Govindharajalu Geetha4, Ramasamy Venkatanarayanan5

    1Department of Pharmacology, PSG College of Pharmacy, Coimbatore-04, India.

    2Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore-04, India.

    3School of Pharmacy, UCSI University, Kula Lumpur, Malaysia.

    4Department of Pharmaceutical Analysis, PSG College of Pharmacy, Coimbatore-04, India.

    5Department of Pharmacognosy, RVS College of Pharmacy, Coimbatore-04, India.

    Pharmacognosy Communications,2012,2,2,50-60
    DOI: 10.5530/pc.2012.2.8
    Published:April 2012
    Type: Research Article

    ABSTRACT

    Introduction: Obesity is a major factor in causing of atherosclerosis. Tetrahydrocurcumin (THC) may prevent atherosclerosis in high-fat diet-induced hypercholesteremic animals. However, the effect of tetrahydrocurcumin on HMG-CoA reductase and lipoprotein lipase enzymes levels in high-fat diet (HFD)-induced hyperlipidemia rabbits remains unexamined. Therefore, beneficial effect of THC on HMG-CoA reductase and lipoprotein lipase enzymes levels in an animal model with high-fat diet (HFD)-induced hyperlipidemia were examined. In addition, measurement of lipid parameters, anti-oxidant enzyme levels and histopathology studies were also performed. Methods: Healthy adult male New Zeland white rabbits (2.0 to 2.5 kg) were used in these studies. A high fatty diet was prepared and fed to the rabbits. Tetrahydroxycurcumin (THC) suspensions (40mg /kg and 80 mg/kg body weight) were given orally to the high-fat diet animals. Simvastatin (20mg/kg body weight) was used as standard drug. The blood was collected and measurement of lipid profiles and antioxidant enzymes levels were performed. In addition, the histopathology studies were performed for all groups. Results: Treatment with a high dose of THC (80 mg/kg) showed enhanced hypolipidemic activity compared to a lower dose of THC (40 mg/kg) in high-fat diet (HFD)-induced hyperlipidemia animals. The THC suspensions also possess potent antioxidant activities as demonstrated by their enhanced superoxide dismutase, catalase activity and suppressed lipid peroxidase activity. THC (80 mg/kg) exhibited induction of lipoprotein lipase activity and significantly decreased cholesterogenesis in liver by reducing HMG-CoA reductase activity. Conclusion: The results of the present study suggest that THC at a dose 80 mg/kg prevented the development of atherosclerosis in high-fat diet (HFD)-induced hyperlipidemia animals. These protective effects may be associated with the potent antioxidant activities of THC.

    Key Words: Tetrahydrocurcumin, HMG-CoA reductase, lipoprotein lipase, atherosclerosis

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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