Facebook Twitter Instagram
    Trending
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    • Medicinal Plant Images
    • Upcoming Events
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    Research Article

    Carbonic Anhydrase I and II Inhibition with Natural Products: Leucas cephalotes

    October 1, 2011Updated:August 11, 20212 Mins Read

    Kalyan K. Sethia, Saurabh M. Vermab, P. Mahesh Kumara, Rahul Mishrab, Claudiu T. Supuranc

    aGITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P., 530045, India.

    bDepartment of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi-835215, India.

    cLaboratorio di Chimica, Bioinorganica, Università, degli Studi di Firenze, Rm 188, Via della, Lastruccia 3, I‑50019 Sesto, Fiorentino (Firenze), Italy.

    Pharmacognosy Communications,2011,1,2,41-47
    DOI: 10.5530/pc.2011.2.8
    Published: April 2011
    Type: Research Article

    ABSTRACT

    Carbonic anhydrases (EC 4.2.1.1) are ubiquitous metalloenzymes present in prokaryotes and eukaryotes that are encoded by five evolutionarily unrelated gene families are involved in numerous physiological and pathological processes. Novel interesting chemo types, in addition to the sulphonamide and sulfamate were discovered, many of which are based on natural products, such as phenols/polyphenols, phenolic acids, and coumarins. Methanolic extract of Leucas cephalotes belongs to family Labiatae (or Lamiaceae) tested for human carbonic anhydrase (hCA) I and II inhibition study. The significant IC 50 values are calculated for the methanolic extract of Leucas cephalotes for hCA I found to be 0.23 mM/ml which is showing relatively less potent then hCA inhibition against hCA II having IC 50 values of 0.19 mM/ml. Leucas cephalotes is a weak inhibitors they may constitute leads for developing tighter binding compounds.

    Key words: Carbonic anhydrase; Enzyme inhibitor; Natural product; Leucas cephalotes.

    Download PDF

    Related Posts

    Molecular Docking of some Neem Constituents with COX-2 and NOs: An in silico Study

    July 1, 2020

    Trachiyspirum ammi (L.) Sprague ex Turrill Seed Extracts Lack Antibacterial Activity

    July 1, 2020

    Traditional Medicinal Knowledge in India and Malaysia

    February 2, 2015
    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    Facebook Twitter Instagram Pinterest
    © 2023 Phcog.net. Designed by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up