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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Carbonic Anhydrase I and II Inhibition with Natural Products: Leucas cephalotes

    wadmin1By wadmin1October 1, 2011Updated:August 11, 2021No Comments2 Mins Read
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    Kalyan K. Sethia, Saurabh M. Vermab, P. Mahesh Kumara, Rahul Mishrab, Claudiu T. Supuranc

    aGITAM Institute of Pharmacy, GITAM University, Rushikonda, Visakhapatnam, A.P., 530045, India.

    bDepartment of Pharmaceutical Sciences, Birla Institute of Technology, Mesra Ranchi-835215, India.

    cLaboratorio di Chimica, Bioinorganica, Università, degli Studi di Firenze, Rm 188, Via della, Lastruccia 3, I‑50019 Sesto, Fiorentino (Firenze), Italy.

    Pharmacognosy Communications,2011,1,2,41-47
    DOI: 10.5530/pc.2011.2.8
    Published: April 2011
    Type: Research Article

    ABSTRACT

    Carbonic anhydrases (EC 4.2.1.1) are ubiquitous metalloenzymes present in prokaryotes and eukaryotes that are encoded by five evolutionarily unrelated gene families are involved in numerous physiological and pathological processes. Novel interesting chemo types, in addition to the sulphonamide and sulfamate were discovered, many of which are based on natural products, such as phenols/polyphenols, phenolic acids, and coumarins. Methanolic extract of Leucas cephalotes belongs to family Labiatae (or Lamiaceae) tested for human carbonic anhydrase (hCA) I and II inhibition study. The significant IC 50 values are calculated for the methanolic extract of Leucas cephalotes for hCA I found to be 0.23 mM/ml which is showing relatively less potent then hCA inhibition against hCA II having IC 50 values of 0.19 mM/ml. Leucas cephalotes is a weak inhibitors they may constitute leads for developing tighter binding compounds.

    Key words: Carbonic anhydrase; Enzyme inhibitor; Natural product; Leucas cephalotes.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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