Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Research Article

    Hypoglycaemic and Antioxidant Activities of the Stem Bark of Morinda Lucida Benth in Streptozotocin – Induced Diabetic Rats

    wadmin1By wadmin1October 1, 2011Updated:August 7, 2021No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    1T. C. Fleischer, 2J.A. Sarkodie, 2G. Komlaga, 3G. Kuffour, 2R. A. Dickson, 2M. L. K. Mensah

    1Department of Herbal Medicine,

    2Department of Pharmacognosy and

    3Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi-Ghana.

    Pharmacognosy Communications,2011,1,2,23-29
    DOI: 10.5530/pc.2011.2.5
    Published: Oct 2011
    Type: Research Article

    ABSTRACT

    Introduction: This work was conducted in order to investigate the hypoglycaemic and antioxidant activity of the stem bark of Morinda lucida Benth (Rubiaceae), which has traditionally been used in Ghana for the management of diabetes mellitus. Methods: The powdered stem bark was successively Soxhlet-extracted with petroleum ether and 70% v/v ethanol, respectively, and were then evaporated to dryness to produce crude petroleum ether (PML) and ethanolic (EML) extracts. The hypoglycaemic activity of PML and EML were determined in streptozotocin–induced diabetic rats. Five groups of six diabetic rats received oral administrations of 100, 200 and 400 mg per kg body weight of PML and EML once daily for 19 days. Glibenclamide (5 mg per kg body weight) was used as positive control while distilled deionised water (2 ml) acted as the diabetic control. Blood glucose levels were monitored initially for 6 hours and subsequently over the full 20 days. Results: All extracts exhibited statistically significant (P < 0.001) hypoglycaemic and substantial antioxidant activities throughout the study period. While EML demonstrated the strongest hypoglycaemic activity 6 hours after administration, PML exhibited the highest activity 24 hours after administration and throughout the rest of the study period. Again, both extracts showed antioxidant activities, however EML was more effective. Conclusion: The results of our investigation indicate that the stem bark of M. lucida possesses hypoglycaemic constituents that are well distributed in both petroleum ether and 70% v/v ethanol extracts. In addition, both extracts also showed considerable antioxidant activity. These results give credibility towards the traditional use of the stem bark of M. lucida as an antidiabetic agent.

    Key words: Morinda lucida, diabetes mellitus, hypoglycaemic activity, antioxidant activity.

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up