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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Research Article

    Procognitive Effects of Hexane Extracts of Michelia Champaca Leaves in Normal and Memory Deficit Mice

    wadmin1By wadmin1October 1, 2011Updated:August 7, 2021No Comments2 Mins Read
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    Hafsa Ahmad, Vasundhara Saxena, Anurag Mishra, Rajiv Gupta*, Shubhini A Saraf
    Faculty of Pharmacy, Dept of Pharmacognosy BBDNITM, Lucknow, India

    Pharmacognosy Communications,2011,1,2,30-36
    DOI: 10.5530/pc.2011.2.6
    Published: Oct 2011
    Type: Research Article

    ABSTRACT

    Introduction: Michelia champaca (Magnoliaceae), commonly known as Svarna champa is a glorious ancient Indian medicinal plant, rich in flavonoids and possessing several folkloric uses, traditionally claimed of having CNS effects. This study was undertaken to ascertain the nootropic potential (memory enhancing effects) of the hexane extracts of the leaves of Michelia champaca (Magnoliaceae) using rectangular maze and Y maze (interoceptive behavioral models). Methods: Hexane extracts of leaves of Michelia champaca (dosed at 100 and 200 mg/kg each) were administered to adult Swiss albino Wistar mice and the effect on acquisition, retention and retrieval of spatial recognition memory was determined, by using rectangular maze and Y maze (interoceptive behavioral models). Bacopa monniera extract was used as the standard drug while Scopolamine hydrobromide served as the amnestic agent. Results: The higher doses of the Michelia champaca extract exhibited a more promising nootropic potential. Maximal response was observed in the 200 mg/kg dose of extract, which closely approximated the results for the standard drug Brahmi. The higher dose elicited greater responses in both the models studied and were comparable to that achieved with the standard drug. Conclusion: The hexane extract of Michelia champaca afforded mild memory enhancing effects, the higher dose evoking pronounced alteration of behavior and better learning assessments.

    Key words: Michelia champaca, memory enhancing, cognitive, HPTLC, Quercetin.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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