Antimicrobial and anti-inflammatory activities of the leaves of Clerodendrum splendens leaves

Fleischer, TC¹, Mensah, AY², Oppong, AB², Mensah, MLK¹, Dickson, RA², Annan, K²

¹Department of Herbal Medicine, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

²Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.

Pharmacognosy Communications,2011,1,1,85-89
DOI:10.5530/pc.2011.1.6
Published: July 2011
Type: Research Letter

ABSTRACT

Clerodendrum splendens is a West African climbing shrub used in traditional medicine for wounds and infectious conditions. The petroleum ether, ethyl acetate, and 70% ethanolic extracts of the leaves obtained by successive Soxhlet extraction, inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Eschericia coli and Candida albican. The ethyl acetate extract was the most active. Again, all the extracts dose-dependently inhibited carrageenaninduced foot paw oedema in 7-day old chicks. Again, the ethyl acetate extract showed the greatest inhibition. The results of this study provide scientific evidence for the ethnomedicinal use of the leaves of C. splendens.

Key words: Clerodendrum splendens, Antimicrobial, Anti-inflammatory activity.