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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Investigating the Pharmacognostic Potential of Indian Terminalia Spp. in the Treatment and Prevention of Yersiniosis

    wadmin2By wadmin2September 6, 2017Updated:August 12, 2021No Comments2 Mins Read
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    Mitchell Henry Wright,a Anthony Carlson Greene,b Ian Edwin Cock,b,c*
    aDivision of Environmental and Biomolecular Systems, Institute of Environmental Health, Oregon Health & Science University, Portland, Oregon, USA.
    bSchool of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.
    cEnvironmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.

    Pharmacognosy Communications,2017,7,3,108-113.
    DOI:10.5530/pc.2017.3.16
    Published: September 2017
    Type: Original Article

    ABSTRACT

    Introduction: Yersinia enterocolitica is a major cause of food poisoning through contaminated meat products, causing the acute gastrointestinal disease yersiniosis. Many Terminalia spp. have documented therapeutic properties as general antiseptics, inhibiting the growth of a wide variety of bacterial species. Despite this, Indian Terminalia spp. extracts have not been tested for the ability to inhibit the growth of Y. enterocolitica. Methods: T. arjuna, T. catappa and T. chebula extracts were extracted by maceration and the extracts were investigated by disc diffusion assay for growth inhibitory activity against a clinical strain of Y. enterocolitica. The MIC values of the extracts were determined to quantify and compare their efficacies. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: T. chebula fruit extracts displayed potent growth inhibitory activity in the disc diffusion assay against Y. enterocolitica. The methanolic and ethyl acetate T. chebula fruit extracts were particularly potent growth inhibitors, with MIC values of 85 and 64 μg/mL respectively. The aqueous fruit extract also displayed good growth inhibitory activity against Y. enterocolitica, albeit with a higher MIC value (653 μg/mL). The T. arjuna branch extract was moderately active (3000 μg/mL). All other extracts were either low efficacy, or completely devoid of growth inhibitory activity. All Indian Terminalia spp. extracts were nontoxic (LC50 values <1000 μg/mL) in the Artemia franciscana bioassay. Conclusions: The lack of toxicity and the potent growth inhibitory bioactivity of the T. chebula extracts against Y. enterocolitica indicates their potential as medicinal agents in the treatment and prevention of yersiniosis.

    Keywords: Terminalia arjuna, Terminalia catappa, Terminalia chebula, Yersinia enterocolitica, Enterobacteriaceae, antibacterial activity, food poisoning, Ayurveda.

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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