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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Melodorum leichhardtii (F.Muell.) Benth. Extracts Inhibit the Growth of Klebsiella pneumoniae

    wadmin1By wadmin1January 1, 2019Updated:August 10, 2021No Comments2 Mins Read
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    Getmore Chikowe1, Lindiwe Mpala1, Ian Edwin Cock1,2,*
    1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, AUSTRALIA.
    2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, AUSTRALIA.

    Pharmacognosy Communications,2019,9,1,15-20.
    DOI:10.5530/pc.2019.1.4.
    Published: January 2019
    Type: Original Article

    ABSTRACT

    Introduction: Melodorum leichhardtii F.Muell. Benth. is a rainforest vine which is native to north-eastern rainforest regions of Australia. Melodorum spp. are rich in a variety of terpenoids with reported antibacterial activity. Despite this, M. leichhardtii leaf extracts have not previously been examined for bacterial growth inhibitory properties. Methods: The antimicrobial activity of a methanolic M. leichhardtii leaf extract was investigated by disc diffusion and growth time course assays against a panel of bacterial pathogens. The growth inhibitory activity was further quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic M. leichhardtii leaf extract was a potent inhibitor of Klebsiella pneumonia (MICs of 388μg/mL). The extract was also a low-moderate inhibitor of B. cereus growth (MICs 3678μg/mL) but was completely devoid of inhibitory activity against all other bacterial species tested. The antibacterial activity of the methanolic M. leichhardtii leaf extract was further investigated by growth time course assays that showed significant growth inhibition in cultures of K. pneumoniae and B. cereus within 1 h of exposure. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for use in preventing diseases caused by these pathogens. Conclusion: The lack of toxicity of the M. leichhardtii leaf extracts and their growth inhibitory bioactivity against K. pneumoniae and B. cereus indicate their potential in the development of new therapies targeting these bacteria.

    Key words: Annonaceae, Zig-zag vine, Australian plant, Traditional medicine, Antibacterial, Ankylosing spondylitis, Eudesmol.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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