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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    An Examination of the Antibacterial, Antifungal, Anti-Giardial and Anticancer Properties of Buchanania obovata Engl. Fruit Extracts

    wadmin1By wadmin1January 1, 2019Updated:August 10, 2021No Comments2 Mins Read
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    Cécile Mazerand1,2, Ian Edwin Cock1,3*
    1School of Environment and Science, Griffith University, Brisbane, 4111, AUSTRALIA.
    2School of Biology, Ecole de Biologie Industrielle (EBI), Cergy, FRANCE.
    3Environmental Futures Research Institute, Griffith University, Brisbane, AUSTRALIA.

    Pharmacognosy Communications,2019,9,1,7-14.
    DOI:10.5530/pc.2019.1.3.
    Published: January 2019
    Type: Original Article

    ABSTRACT

    Background: Buchanania obovata is an endemic Australian plant that has been used traditionally to treat a variety of bacterial, fungal and protozoal pathogenic diseases. This study was undertaken to test B. obovata fruit extracts for the ability to inhibit microbial and cancer cell growth. Materials and Methods: B. obovata fruit powder was extracted and tested for antimicrobial activity using disc diffusion and MIC methods. Inhibitory activity against the gastrointestinal protozoal parasite Giardia duodenalis and antiproliferative activity against human colorectal (Caco2) and cervical (HeLa) cancer cell lines was evaluated using MTS-based colorimetric assays. Toxicity was evaluated using an Artemia franciscana nauplii bioassay. Results: The methanol, water and ethyl acetate B. obovata fruit extracts displayed potent antibacterial activity. The methanol and water extracts displayed the broadest specificity, inhibiting the growth of all of the Gram positive and Gram negative bacterial species tested. The ethyl acetate extract also displayed antibacterial activity, inhibiting the growth of 7 (88%) of the Gram negative and 2 (50%) of the Gram positive bacterial species. The methanol extract also displayed broad spectrum antifungal activity, inhibiting the growth of all 3 fungal species, including an ampicillin resistant strain of A. niger. The water extract also inhibited the growth of 2 (66%) of the fungal species tested. None of the extracts were particularly good inhibitors of the growth of the gastrointestinal parasite Giardia duodenalis. The methanolic and aqueous extracts were effective at blocking the proliferation of the colorectal cancer cell line Caco2 to between approximately 20 and 30% of the untreated cell growth. All extracts also inhibited HeLa cervical cancer cell growth. The methanol, water and ethyl acetate extracts displayed substantial toxicity in the Artemia nauplii assay. Conclusion: This study shows that B. obovata fruit extracts inhibit bacteria and fungi, but are relatively ineffective against G. duodenalis. The extracts were also effective inhibitors of Caco2 and HeLa cell proliferation, indicating that the extracts have potential in the treatment of microbial diseases and some cancers.

    Key words: Antibacterial activity, Anticancer activity, Antiproliferative activity, Artemia, Giardia duodenalis, Green plum, Toxicity.
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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