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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    The Inhibitory Activity of Mischarytera lauteriana (F.M.Bailey) Leaf Extracts against a Panel of Bacterial Pathogens

    wadmin1By wadmin1April 1, 2019Updated:August 9, 2021No Comments2 Mins Read
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    Lindiwe Mpala1, Getmore Chikowe1, Ian Edwin Cock1,2,*

    1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland,

    Pharmacognosy Communications,2019,9,2,47-53.
    DOI:10.5530/pc.2019.2.11
    Published: April 2019
    Type: Original Article

    ABSTRACT

    Introduction: The development of multi-antibiotic resistant strains of bacteria has necessitated the search for new, effective antibacterial therapies. M. lauteriana was used by Australian Aborigines as a nutritious food. However, very little research has been published on this species and the antibacterial activity of M. lauteriana leaf extracts has not yet been reported. Methods: The ability of M. lauteriana leaf extracts to inhibit the growth of gram-negative and gram-positive bacterial species was investigated by disc diffusion and growth time course assays. The growth inhibitory activity was further quantified by MIC determination. Toxicity was determined using the Artemia franciscana nauplii bioassay. Results: The methanolic and aqueous M. lauteriana leaf extracts were good inhibitors of the growth of both gram-positive and gram-negative bacteria. The methanolic extract was a particularly good inhibitor of K. pneumoniae and B. cereus growth, with MIC values of 728 and 515μg/mL respectively. The aqueous extract was also a good inhibitor of these bacteria (MICs of 953 and 860μg/mL respectively). Whilst the M. lauteriana leaf extracts also inhibited the growth of P. mirabilis, S. aureus and S. pyogenes, the MIC values (in the range 1000-2000μg/mL) were indicative of moderate inhibitory activity. The M. lauteriana leaf extracts were further investigated by growth time course assays against K. pneumoniae and B. cereus. Interestingly, both extracts showed significant growth inhibition within 1h of exposure against both bacterial species. All extracts were determined to be nontoxic in the Artemia franciscana nauplii bioassay, indicating their safety for the treatment of gram-positive bacterial infections. Conclusion: The lack of toxicity of the M. lauteriana leaf extracts and their growth inhibitory bioactivity against multiple bacteria indicate their potential in the development of new antibiotic chemotherapies.

    Keywords:ankylosing spondylitis, Antibacterial, Antibiotic resistant bacteria, Bacillus cereus, Corduroy tamarind, Klebsiella pneumoniae, Sapindaceae, Traditional medicine

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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