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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Rapid Screening using GIBEX Screens-to-nature System of Ethnomedicinal Plants from Ngong Forest, Kenya for Potency against Infectious Diseases and Antioxidant Activities: A Qualitative Study

    wadmin1By wadmin1April 1, 2019Updated:August 9, 2021No Comments2 Mins Read
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    Leonidah Kerubo Omosa1, Beatrice Amugune2, Peggoty Mutai3, Esther Karumu3, Nilian Mukungu3, Martha Induli4, Francisca Kama-Kama1, Victor Kuete5

    1Department of Chemistry, School of Physical Sciences, University of Nairobi, Nairobi, KENYA.

    2Department of Pharmaceutical Chemistry, School of Pharmacy, University of Nairobi, Nairobi, KENYA.

    3Department of Pharmacology and Pharmacognosy, School of Pharmacy, University of Nairobi, Nairobi, KENYA.

    4Department of Research, Technology and Innovation, Kenya Industrial Research and Development Institute, Nairobi, KENYA.

    5Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, CAMEROON.

    Pharmacognosy Communications,2019,9,2,59-74.
    DOI:10.5530/pc.2019.2.13
    Published: April 2019
    Type: Original Article

    ABSTRACT

    Introduction: Plants from Kenyan flora are traditionally used to manage a number of ailments including; chronic and infectious disease, to bolster the body immunity and for general health protections. The current investigation was designed to validate the quality with respect to the pharmacological significance of 156 fresh plant materials resulting from 27 ethno-medicinal plants, from Ngong forest, Kenya. Materials and Methods: Pharmacological screening was carried out using the field deployable GIBEX Screens- To-Nature (STN) validated assays. The plant extracts were screened for antifungal; general protozoal lethality; round worm lethality and antioxidant potential. Results: Different plant parts exhibited a range of activities; related to their traditional uses; with eleven out of twenty-seven extracts exhibiting highest activities in only one out of four categories of assays studied. All plant parts of only one plant C. axillaris exhibited high activities in all (4/4) the categories of assays evaluated. The other plants that exhibited high activities in three out of four (3/4) categories of assays studied included; A. oppositifolia, B. huillensis and T. trichocarpa. Conclusion: The current investigation provided additional data in relation to the usefulness of the studied ethno-medicinal plants, mostly of the following plants; C. axillaris, A. oppositifolia, B. huillensis and T. trichocarpa in the management of diseases that are infectious and to bolster the immunity. The reported data will contribute towards authenticating the claimed traditional use of these plants. The extracts that exhibited high activities should be investigated further to determine their effective concentrations.

    Keywords:Antifungal, Antihelmintic, Antiprotozoal, Free radical Scavenger, Kenyan plant

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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