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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Antiplasmodial Biflavanones from the Stem Bark of Garcinia buchananii Engl.

    wadmin1By wadmin1June 1, 2019Updated:August 10, 2021No Comments2 Mins Read
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    Ruth Anyango Omole1,2,*, Mainen Julius Moshi1, Matthias Heydenreich3, Hamisi Masanja Malebo4, Jeremiah Waweru Gathirwa5, Richard Owor Oriko6, Leonida Kerubo Omosa6, Jacob Ogweno Midiwo6

    1Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, TANZANIA.

    2Department of Chemical Science and Technology, Technical University of Kenya, Nairobi, KENYA.

    3Institut für Chemie, Universität Potsdam, OT Golm, Haus 25, D/0.19 (Labor E/0.06-0.08), Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, GERMANY.

    4Department of Traditional Medicine Research, National Institute for Medical Research, Dar es Salaam, TANZANIA.

    5Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), Nairobi, KENYA.

    6Department of Chemistry, University of Nairobi, Chiromo Road, Nairobi, KENYA.

    .Pharmacognosy Communications,2019,9,3,96-99.
    DOI:10.5530/pc.2019.3.20
    Published:June 2019
    Type:Original Article

    ABSTRACT

    Introduction: Plants of the genus Garcinia are traditionally used treat a range of infectious and non-infectious diseases. Garcinia species are reported to have been shown to have a range of biological activities including cytotoxicity antimicrobial, antifungal, antioxidant, antimalarial and HIV-1 protease inhibitory activity among others. Methods: Solvent extraction was done using CH2Cl2: MeOH (1:1). Isolation was done using column chromatography with silica gel as the stationery phase and ethyl acetate and n-hexane used as mobile phase in increasing polarity. Thin layer chromatography was used to monitor the isolation. Structure elucidation was done using nuclear magnetic resonance and mass spectroscopic techniques. Chloroquine resistant (W2) and chloroquine sensitive (D6) P. falciparum strains were used for antiplasmodial assay. Results: Further bioassay guided fractionation of a CH2Cl2: MeOH (1:1) extract of Garcinia buchananii led to the isolation of two already reported biflavanones, isogarcinol (1) and guttiferone (2) with promising antiplasmodial activity against a chloroquine resistant (W2) Plasmodium falciparum strain with an IC50 of 2.8 ± 0.90 μg/mL for compound 1 and IC50 of 3.94 ± 0.38 μg/mL for compound 2. Compounds 1 and 2 also exhibited moderate activity against the chloroquine sensitive (D6) Plasmodium falciparum strain with IC50 of 7.03±0.60 and 10.64±4.50 μg/mL, respectively. Conclusion: The results provide proof to support the use of G. buchananii by the indigenous community for antimalarial therapy.

    Keywords:Antiplasmodial activity, Garcinia buchananii, Guttiferone F, Isogarcinol
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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