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The Janus Corner

Ian Edwin Cock1,2,*

1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

2Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

Pharmacognosy Communications,2019,9,3,118-120.
DOI:10.5530/pc.2019.3.24
Published:June 2019
Type:The Janus Corner

ABSTRACT

The neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinium are amongst the most poisonous proteins known. These toxins block neurotransmitter release by cleaving N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins, inducing paralysis. In a recent study published in Applied and Environmental Microbiology,1 300 natural compounds isolated from a panel of Indian medicinal plants were screened by biochemical and cellular assays for the ability to antagonise the catalytic active site of BoNT, thereby inhibiting the activity of the protein. Nitrophenyl psoralen (NPP) was identified as a potent inhibitor of BoNT activity, with an IC50 of <4 μM. Furthermore, NPP can also reverse BoNT associated muscle paralysis in a murine model and have low toxicity in humans. Indeed, multiple psoralen derivative drugs are already approved by the US FDA, thereby potentially simplifying the drug approval process for NPP. Read more. . .

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