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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    The Janus Corner

    The Janus Corner

    wadmin1By wadmin1June 1, 2019Updated:August 10, 2021No Comments1 Min Read
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    Ian Edwin Cock1,2,*

    1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    2Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    Pharmacognosy Communications,2019,9,3,118-120.
    DOI:10.5530/pc.2019.3.24
    Published:June 2019
    Type:The Janus Corner

    ABSTRACT

    The neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinium are amongst the most poisonous proteins known. These toxins block neurotransmitter release by cleaving N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins, inducing paralysis. In a recent study published in Applied and Environmental Microbiology,1 300 natural compounds isolated from a panel of Indian medicinal plants were screened by biochemical and cellular assays for the ability to antagonise the catalytic active site of BoNT, thereby inhibiting the activity of the protein. Nitrophenyl psoralen (NPP) was identified as a potent inhibitor of BoNT activity, with an IC50 of <4 μM. Furthermore, NPP can also reverse BoNT associated muscle paralysis in a murine model and have low toxicity in humans. Indeed, multiple psoralen derivative drugs are already approved by the US FDA, thereby potentially simplifying the drug approval process for NPP. Read more. . .

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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