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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    Original Article

    Hematopoietic Effect of Amaranthus cruentus Extract on Cyclophosphamide Induced Toxicity in Rats

    wadmin1By wadmin1September 1, 2019Updated:August 10, 2021No Comments1 Min Read
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    Stuti Pandey, Aditya Ganeshpurkar*, Nazneen Dubey

    Shri Ram Institute of Technology-Pharmacy, Jabalpur, Madhya Pradesh, INDIA.

    Pharmacognosy Communications,2019,9,4,139-142.
    DOI:10.5530/pc.2019.4.29
    Published:September 2019
    Type:Original Article

    ABSTRACT

    Introduction: Amaranthus cruentus (Amaranthaceae) is one of the popularly grown leafy vegetables in the Indian subcontinent. The leaves of the plant are rich in polyphenols, tannins, flavonoids, steroids, terpenoids, saponins and betalains. The plant is also rich in protein, calcium, iron, as well as vitamins A, E, C and folic acid. The present work was undertaken to evaluate the anti-anemic effects of Amaranthus cruentus. Methods: An ethanol extract of Amaranthus cruentus was prepared and the of folic acid, ascorbic acid, iron, polyphenol and flavonoid contents were estimated. Acute oral toxicity of the extract was determined according to OECD guideline-423 at doses of 200 mg/kg and 400 mg/kg. Cyclophosphamide (0.3 mg/kg, i.p.) was used to induce anemia in rats. After anemia induction, animals were treated with standard preparation (Ferritop Syrup) and the extract. Results: Amaranthus cruentus extract significantly aided to restore the levels of RBCs, WBCs, hemoglobin and increased hematocrit levels. Conclusion: Thus, it was concluded that Amaranthus cruentus is a rich source of phytochemicals that demonstrate hematopoietic effects.

    Keywords:Amaranthus cruentus, Anemia, Cyclophosphamide, Hematocrit, Hematopoietic
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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