Facebook Twitter Instagram
    Trending
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    • Medicinal Plant Images
    • Upcoming Events
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    Original Article

    Protective Effect of Hesperidin on Humoral and Cell-mediated Immunity in Rat Model

    April 1, 2020Updated:August 9, 20212 Mins Read

    Aditya Ganeshpurkar1,2,3 Ajay Saluja1,2,*
    1Faculty of Pharmacy, Gujarat Technological University, Ahmedabad, Gujarat, INDIA.
    2Shri Ram Institute of Technology- Pharmacy, Jabalpur, Madhya Pradesh, INDIA.
    3CVM’s A.R. College of Pharmacy, Vallabh Vidyanagar, Anand, Gujarat, INDIA.

    Pharmacognosy Communications,2020,10,2,83-88.
    DOI:10.5530/pc.2020.2.16
    Published: April 2020
    Type: Original Article

    ABSTRACT

    Context: Hesperidin, an important bioflavonoid, is abundantly found in various foodstuffs and can be regarded as an essential nutraceutical. Hesperidin has been acknowledged for its protective and beneficial effects on various aspects of biological system. Objectives: The present study was aimed to examine the effect of hesperidin on the regulation of the immune response in experimental animal models. Materials and Methods: The immunomodulatory effects of hesperidin were determined in rats using different experimental models including carbon clearance test, cyclophosphamide-induced neutropenia, neutrophil adhesion test, effect on serum immunoglobulin, neutrophil adhesion and indirect hemagglutination test. Hesperidin was administered orally at doses of 25, 50 and 100 mg/ kg p.o. Cyclophosphamide (30 mg/kg p.o.) was used as a standard immunosuppressant. Results: Hesperidin in all test doses demonstrated notable immunomodulatory responses in a sheep red blood cell challenge model. There was a refurbishment in the functioning of leucocytes in cyclophosphamide- treated rats and an increased clearance of carbon particles. The antibodytiter in the hemagglutination test showed increased levels of immunoglobulin. Discussion and Conclusion: The results of the present study indicate that hesperidin possesses sufficient potential for modulating immune activity by cellular and humoral mediated mechanisms.

    Key words: Hesperidin, Immunity, Antibody, Myelosuppression, Immunoglobulin.

    Download PDF

    Related Posts

    Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases

    July 20, 2023

    Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease

    July 20, 2023

    Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines

    July 20, 2023
    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    Facebook Twitter Instagram Pinterest
    © 2023 Phcog.net. Designed by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up