Huperzinea: Pharmacological and Therapeutic Potential

Shagun Dubey (Upadhyay)1,*, Yusra Ahmad2, Rajesh Kumar Sharma3, Seema Kohli1

1Department of Pharmacy, Government Kalaniketan Polytechnic College, Jabalpur, Madhya Pradesh, INDIA.

2Faculty of Pharmacy, Uttarakhand Technical University, Dehradun, Uttarakhand, INDIA.

3College of Veterinary Science and Animal Husbandry, Nanaji Deshmukh University of Veterinary Science, Jabalpur, Madhya Pradesh, INDIA.

Pharmacognosy Communications,2020,10,4,146-149.
Published: December 2020
Type: Original Article


Introduction: Huperzine A (HupA) is derived from a club moss (Huperzia serrata). It is a potent and reversible inhibitor of acetyl cholinesterase (AChE). Chemically, it is a sesquiterpene alkaloid. It has been used for the treatment of swelling, fever and blood disorders for centuries in China. Methodology: The literature available on Huperzine was thoroughly studied. It has shown much beneficial effect since ages. It is a established Nootropic agent and widely used in the treatment of Alzheimer’s disease. The plant has shown promising results in vivo and in vitro studies. Results and Conclusion: The present review highlights the pharmacological potential of Huperzine with its pharmacokinetic and pharmacokinetic studies and it’s rational for future prospective.

Key words: Huperzine, Neuroprotective agent, Pharmacokinetics, Pharmacology.
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