Lakshmi Kanta Kanthal1, Prasenjit Mondal2,*, Rekhabai Thakur3, Surajit Maity1, Palepu Kavi4, Palaka Balaji Srinu4
1Department of Pharmacology, Haldia Institute of Pharmacy, ICARE Complex, Haldia, Purba Medinipur, West Bengal, INDIA.
2Department of Pharmaceutical Chemistry, Vaageswari Institute of Pharmaceutical Sciences, Karimnagar, Telangana, INDIA.
3Department of Pharmacy, Vaageswari College of Pharmacy, Karimnagar, Telangana, INDIA.
4Department of Pharmacology, Koringa College of Pharmacy, Korangi, Tallarevu, East Godavari, Andhra Pradesh, INDIA.
Published: December 2020
Type: Original Article
Introduction: The present study was to investigate the phytocomponents by using GC-MS analysis, in-vitro antioxidant activity and the anthelmintic property of ethanolic extract of Borassus flabellifer Linn (EEBFL) root. Methods: EEBFL was prepared from roots of B. flabellifer by cold maceration. EEBFL was used to analyse phytocomponents by GCMS and the in-vitro antioxidant activity was quantified using are low he ABTS method. Anthelmintic activity was studied on Pheritima posthuma. Results: The phytochemical investigation by GC-MS study identified 15 components in the extract of B. flabellifer. In antioxidant activity, the percentage scavenging range from 32.33% to 61.66% (IC50 160±2.5) and by standard drug (ascorbic acid) 48.33% to 70.66% (IC50 105±4.33) using the ABTS method. For anthelmintic activity, EEBFL showed paralysis time ranging from 107 min to 127 min and a death time ranging from 148 min to 177 min comparted to the standard drug Albendazole (paralysis time 94 min to 62 min and death time 124 min to 136 min on Pheritima posthuma). Conclusion: Ethanolic B. flabellifer Linn root extract is an effective agent in the management of antioxidant and anthelmintic activities due to presence of biologically active phytocomponents.
Key words: ABTS, Ascorbic acid, B. flabellifer, GC-MS study, Pheritima posthuma.