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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Astrotrichia latifolia Benth. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro

    wadmin1By wadmin1January 1, 2021Updated:August 6, 2021No Comments2 Mins Read
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    Lindiwe Nomathemba Mpala1, Getmore Rumbudzai Chikowe2, Ian Edwin Cock1,2,*

    1School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    Pharmacognosy Communications,2021,11,1,40-44.
    DOI:10.5530/pc.2021.1.9
    Published: January 2021
    Type: Original Article

    ABSTRACT

    Introduction: The recent development of extensively antibiotic resistant bacteria has necessitated the search for novel antibacterial compounds. An examination of aromatic plants and traditional medicines is an attractive option for drug discovery. Astrotrichia latifolia Benth. is a native Australia shrub that has yet to be tested for antibacterial activity. Methods: The ability of A. latifolia leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: A. latifolia leaf methanolic and aqueous extracts were completely ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were non-toxic in the Artemia nauplii bioassay following 24 h exposure. Conclusion: A. latifolia leaf extracts were completely ineffective bacterial growth inhibitors. However, these extracts may have other therapeutic properties and testing against protozoa, virus and tumour cells is required.

    Key words: Antibacterial activity, Araliaceae, Australian plant, Broad-leaf star hair, Medicinal plants, Toxicity, Traditional medicine.
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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