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    Pharmacognosy Communications
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    Pharmacognosy Communications
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    The Janus Corner

    Extracts Prepared from Punica granatum L. Peel Inhibit SARSCoV-2 Virus Infection

    wadmin1By wadmin1January 1, 2021Updated:August 6, 2021No Comments2 Mins Read
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    Dr. Ian Edwin Cock1,2,*

    1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, AUSTRALIA.

    2Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, AUSTRALIA.

    Pharmacognosy Communications,2021,11,1,61.
    DOI:10.5530/pc.2021.1.12
    Published: January 2021
    Type: The Janus Corner

    ABSTRACT

    The SARS-CoV-2 virus that causes the current COVID-19 pandemic is an enveloped RNA virus that has been the focus of much research in the last year. Whilst the majority of efforts to combat this pandemic have focussed on the development of an effective vaccine, other researchers have turned to pharmacognosy in an effort to discover effective treatments. A recent study from the Department of Pharmacognosy at University of Banja Luka in Bosnia and Herzegovina has highlighted the potential of Punica granatum L. (commonly known as pomegranate) peel extracts in preventing SARS-CoV-2 infections.1 Punica granatum peel contains substantial levels of hydrolysable tannins including gallic acid, ellagic acid, punicalagin and punicalin, as well as notable flavonoids and anthocyanins, with reported therapeutic properties. Notably, P. granatum extracts have previously been reported to inhibit infections in humans of influenza virus, herpes virus, poxviruses and human immunodeficiency virus (HIV). The researchers of this study screened P. granatum extracts and pure tannins against four protein targets that facilitate SARS-CoV-2 entry into howst cells (SARS-CoV-s spike glycoprotein, angiotensinconverting enzyme-2, furin and transmembrane serine protease 2). Of the tested compounds, punicalagin and punicalin displayed noteworthy interactions with the selected proteins. Whether this translates to decreased infection rates in vivo is yet to be determined. Read more…

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    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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