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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Mirbelia oxylobioides F. Muell. Leaf Extracts Lack Antibacterial Activity and are Non-toxic in vitro

    Web AdminBy Web AdminApril 1, 2021Updated:August 4, 2021No Comments2 Mins Read
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    Ian Edwin Cock1,2,*

    1Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    2School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA.

    Pharmacognosy Communications,2021,11,2,95-99.
    DOI:10.5530/pc.2021.2.19
    Published: April 2021
    Type: Original Article

    ABSTRACT

    Introduction: The development of bacterial strains that are resistant to multiple antibiotics has made the discovery of new antibiotics a priority for medical research. Examination of plants for new antimicrobial agents is an attractive prospect and numerous recent studies have screened plants for antibacterial activity. Despite this, Australian native plants have been relatively neglected. Mirbelia oxylobioides F.Muell. is a native Australian shrub of the family Fabaceae. Very few studies have yet examined species for antibacterial properties against human pathogens. Methods: The ability of M. oxyloboides leaf extracts to inhibit the growth of a panel of bacterial pathogens was investigated by disc diffusion assay. Toxicity was examined using the Artemia franciscana nauplii bioassay. Results: M. oxyloboides methanolic and aqueous extracts were ineffective at inhibiting the growth of gram-positive and gram-negative panels of bacteria. The extracts were nontoxic or of low toxicity following 24 h exposure. Conclusion: The M. oxyloboides leaf extracts lacked growth inhibitory bioactivity against a panel of pathogenic bacteria and were nontoxic in the Artemia nauplii assay. However, these extracts may have other therapeutic properties and testing against protozoa, fungi, virus and tumour cells is required.

    Key words: Australian plants, Fabaceae, Medicinal plants, Mountain mirbelia, Sandstone bushpea, Toxicity, Traditional medicine
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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