Facebook Twitter Instagram
    Trending
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    • Medicinal Plant Images
    • Upcoming Events
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    Review Article

    Toxicological Significance of Bioactive Compounds of Plant Origin

    April 1, 2021Updated:August 11, 20212 Mins Read

    Franklyn Okechukwu Ohiagu1, Paul Chidoka Chikezie1,*, Chinwendu Maureen Chikezie2

    1Department of Biochemistry, Imo State University, Owerri, NIGERIA.

    2Department of Biochemistry, Federal University of Technology, Owerri, NIGERIA.

    Pharmacognosy Communications,2021,11,2,67-77.
    DOI:10.5530/pc.2021.2.15
    Published:April 2021
    Type:Review Article

    ABSTRACT

    Aim/Background: The evaluation of toxicological significance of medicinal plants is necessary prior to their use for drug development or for the purpose of improving the therapeutic efficacy of existing therapies. Regrettably, there is little information on the toxicity profiles of the chemical constituents of commonly used medicinal plants. Meanwhile, available information on the toxicity concerns of the use of medicinal plants are often taken for granted and ignored. Materials and Methods: The information and data used in this review report were sourced from scientific databases such as Google Scholar, PubMed, SpringerLink, Medline, ScienceDirect, and Mendeley. Results: The noxious chemical compounds in plants may be neurotoxic, mutagenic or cytotoxic. They may disrupt metabolic processes in living organisms and adversely affect the skin and the mucosal tissues, etc. It is noteworthy that the beneficial as well as the toxicological outcomes following the use of plant materials depends on the chemical nature of their constituent bioactive compounds. Conclusion: Plants, especially those used for ethnomedicinal purposes, contain significant amounts of noxious bioactive compounds, which may elicit adverse health effects on both humans and other animals. The isolation and purification of plant bioactive compounds for toxicological evaluation prior to their usage in the development of pharmaceutical formulations is recommended.

    Keywords: Bioactive compounds, Cytotoxins, Neurotoxins, Plant, Toxicological significance
    Download PDF

    Related Posts

    Potentials of Endophytic Fungus Untapped, including Novel Bioactive Compounds

    May 5, 2023

    Scientific Update on the Pharmacognostic, Pharmacological and Phytochemical Properties of Thevetia peruviana

    January 23, 2023

    Exploration of Streptomyces hygroscopicus Secondary Metabolite Compound as a Development of Antimalarial Drug Candidate

    December 24, 2021
    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
    • Therapeutic Potential of Arctium lappa L. Root Extracts to Inhibit Gastrointestinal Bacterial Pathogens and Treat Gastrointestinal Disease
    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
    Facebook Twitter Instagram Pinterest
    © 2023 Phcog.net. Designed by EManuscript.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up