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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Review Article

    Toxicological Significance of Bioactive Compounds of Plant Origin

    Web AdminBy Web AdminApril 1, 2021Updated:August 11, 2021No Comments2 Mins Read
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    Franklyn Okechukwu Ohiagu1, Paul Chidoka Chikezie1,*, Chinwendu Maureen Chikezie2

    1Department of Biochemistry, Imo State University, Owerri, NIGERIA.

    2Department of Biochemistry, Federal University of Technology, Owerri, NIGERIA.

    Pharmacognosy Communications,2021,11,2,67-77.
    DOI:10.5530/pc.2021.2.15
    Published:April 2021
    Type:Review Article

    ABSTRACT

    Aim/Background: The evaluation of toxicological significance of medicinal plants is necessary prior to their use for drug development or for the purpose of improving the therapeutic efficacy of existing therapies. Regrettably, there is little information on the toxicity profiles of the chemical constituents of commonly used medicinal plants. Meanwhile, available information on the toxicity concerns of the use of medicinal plants are often taken for granted and ignored. Materials and Methods: The information and data used in this review report were sourced from scientific databases such as Google Scholar, PubMed, SpringerLink, Medline, ScienceDirect, and Mendeley. Results: The noxious chemical compounds in plants may be neurotoxic, mutagenic or cytotoxic. They may disrupt metabolic processes in living organisms and adversely affect the skin and the mucosal tissues, etc. It is noteworthy that the beneficial as well as the toxicological outcomes following the use of plant materials depends on the chemical nature of their constituent bioactive compounds. Conclusion: Plants, especially those used for ethnomedicinal purposes, contain significant amounts of noxious bioactive compounds, which may elicit adverse health effects on both humans and other animals. The isolation and purification of plant bioactive compounds for toxicological evaluation prior to their usage in the development of pharmaceutical formulations is recommended.

    Keywords: Bioactive compounds, Cytotoxins, Neurotoxins, Plant, Toxicological significance
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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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