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    Pharmacognosy Communications
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    Pharmacognosy Communications
    retyeyutreu
    Original Article

    FTIR, HPLC, GC-MS Analysis and Investigation of Hypoglycemic Effects of Leaves Extracts of Fagonia indica

    wadmin1By wadmin1April 1, 2021Updated:August 5, 2021No Comments2 Mins Read
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    Atiq-ur-Rehman1,2,4*, Furhan Talib2,3, Tayyaba Aftab2
    1University College of Pharmacy, University of the Punjab, Lahore, PAKISTAN.
    2Faculty of Pharmacy, The University of Lahore, Lahore, PAKISTAN.
    3Sabir Hospital, Qaboola Rd, Arifwala, Pakpattan, PAKISTAN.
    4Faculty of Pharmacy, Hajvery University, Lahore, PAKISTAN.

    Pharmacognosy Communications,2021,11,2,109-118.
    DOI:10.5530/pc.2021.2.21
    Published: April 2021
    Type: Original Article

    ABSTRACT

    Introduction: The present study was aimed for phytochemical analysis, investigations of different functional groups, the hypoglycemic potential of Fagonia indica leaves extracts, Reverse phase high performance liquid chromatography (RP-HPLC) and gas chromatography-mass spectroscopy (GC-MS) analysis of the most active hypoglycemic methanol extract. Methods: After extraction using cold maceration method, phytochemical screening, Fourier Transform Infrared (FTIR) spectroscopy, investigation of in vitro hypoglycemic potential of leaves extracts of the plant by α-glucosidase (sucrase) inhibitory assay were assessed using the standard methods. RPHPLC and GC-MS analysis of the most active methanol extract was done to identify various biologically active compounds. Results: Phytochemical analysis showed various phytochemicals in the plant. FTIR spectral analysis showed diagnostic peaks of various functional groups. Methanol extract of the plant leaves showed the highest sucrase inhibition (37.0±1.4%) at 100 μg/mL concentration. It was followed by aqueous extract (29.1±1%), chloroform extract (27.7±0.5%) and n-hexane extract (25.5±0.9%) at the same concentration. RP-HPLC and GC-MS analysis of methanol extract showed the presence of various compounds with specific retention times. Conclusion: The plant leaves possessed in vitro hypoglycemic potential with competitive inhibition of enzyme sucrase. Methanol extract is the most effective agent in managing diabetes due to the presence of bioactive phytocomponents.

    Key words: Fagonia indica, FTIR spectrum, Functional groups, Phytochemicals, RP-HPLC.

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    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
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    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

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