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    Pharmacognosy Communications
    Uncategorized

    The Janus Corner

    March 12, 2016Updated:August 12, 20212 Mins Read

    I.E.Cock1,2*
    1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.
    2Environmental Futures Centre, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland 4111, Australia.

    Pharmacognosy Communications,2016,6,3,255-258.
    Published: April 2021
    Type: The Janus Corner

    ABSTRACT
    Recent studies have reported that extracts prepared from the medicinal plants Cistus incanus and Pelargonium sidoides prevent HIV from binding to human cells, thereby preventing it from those infecting cells.1,2 The extracts were reported to inhibit a wide range of HIV-1 and HIV-2 clinical isolates, including a viral isolate which is resistant to all other drugs which are generally used as a part of normal anti-retroviral combinational therapies. The phytochemical extract compounds were found to target and bind to viral envelope proteins. The active compounds bind the cellular proteins and prevent them from interacting with host cell surface CD4 receptors. Of further interest, the research team also reported that the extracts not only blocked HIV cell entry, but had similar effects against both Ebola and Marburg viruses. The team speculated that the extracts may also have similar preventative effects against a wider range of enveloped viruses, included influenza viruses and therefore have broad medical implications. Notably, the study also trialled the extracts in long term studies to determine whether prolonged treatment would result in the development of viral resistance and reported no resistant viruses were found. The research has exciting implications. As the extracts have very different antiviral activities to all current clinical therapies, the extracts may be useful complementary therapies for the prevention and treatment of a wide range of viral diseases.Read more. . .
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    Recent Posts
    • Editorial
    • Antimicrobial Activity of Acacia disparrima Benth. and Acacia leiocalyx Pedley Leaf Extracts in Combination with Antibiotics against Bacterial Triggers of Selected Autoimmune Diseases
    • Tasmannia lanceolata (Poir.) A.C.Sm. Berry and Leaf Extracts Inhibit Proliferation and Induce Apoptosis in Selected Human Carcinoma Cell Lines
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    • Bioactive Compounds in Aqueous Extract of Pilis, A Forehead Transdermal Herbal Medicine
    • The Janus Corner
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