Facebook Twitter Instagram
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Facebook Twitter Instagram
    Pharmacognosy Communications
    • Home
    • About Journal
      • Aim and Scope
      • Editorial Board
      • Indexing Info
      • Contact Us
    • Browse Issues
      • Articles in Press
      • Current Issue
      • Past Issues
    • For Authors
      • Instructions to Authors
      • Article Processing Charges
      • Submit your article
      • Downloads
    Pharmacognosy Communications
    retyeyutreu
    Original Article

    Phytochemical Screening and Haem Polymerization Inhibitory Activity of Root Extract and Fractions from Strychnos lucida R. Br.

    Web AdminBy Web AdminApril 10, 2022Updated:April 12, 2022No Comments2 Mins Read
    Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    Share
    Facebook Twitter LinkedIn WhatsApp Pinterest Email

    Uswatun Khasanah1,*, Novia Ariani2, Yumna Nadya Aprilia2, Sri Winarsih1
    1Department of Pharmacy, Faculty of Medicine, Brawijaya University, Malang, East Java, INDONESIA.
    2Undergraduate Student of Pharmacy Program Study, Faculty of Medicine, Brawijaya University, Malang, INDONESIA.
    DOI: 10.5530/pc.2022.2.10

    ABSTRACT

    Background: Strychnos lucida R. Br. is used empirically by people in Eastern Indonesia to treat malaria symptoms. The Indonesian government has set a decrease in malaria morbidity as a long-term target. This study aimed to determine haem polymerization inhibitory activity and screen secondary metabolites of root extract and fractions from S. lucida. Materials and Methods: Screening of secondary metabolites of root extract and fractions were performed using TLC. Crude extract was fractionated using dichloromethane (DCM), ethyl acetate (EA), and N-butanol as solvents. Measurement of haem polymerization inhibition was carried out in vitro using β-haematin. Results: The DCM fraction showed the most effective haem polymerization inhibitory activity (IC50 of 8.96 mg/ml), followed by the n-butanol, aquadest, ethyl acetate, and crude extract. The IC50 values for the DCM, n-butanol, aquadest, and ethyl acetate fractions were smaller than the chloroquine diphosphate. Based on the results of secondary metabolite screening, the DCM fraction of S. lucida root contains terpenoids, alkaloids, and tannins. Conclusion: The content of secondary metabolites influenced the inhibitory activity of haem polymerization in each extract and fraction.

    Key words: Strychnos lucida R. Br., β-haematin, Phytochemical screening, Hemozoin, Fraction, Antimalarial. 

    Download PDF
    Share. Facebook Twitter Pinterest LinkedIn Tumblr WhatsApp Email
    About Journal
    About Journal

    Pharmacognosy Communications [Phcog Commn.] is a quarterly journal published by Phcog.Net. It is a peer reviewed journal aiming to publish high quality original research articles, methods, techniques and evaluation reports, critical reviews, short communications, commentaries and editorials of all aspects of medicinal plant research. The journal is aimed at a broad readership, publishing articles on all aspects of pharmacognosy, and related fields. The journal aims to increase understanding of pharmacognosy as well as to direct and foster further research through the dissemination of scientific information by the publication of manuscripts. The submission of original contributions in all areas of pharmacognosy are welcome.
    Indexed and Abstracted in : Chemical Abstracts, Excerpta Medica / EMBASE, Google Scholar, CABI Full Text, Ulrich’s International Periodical Directory, ProQuest, Journalseek & Genamics, PhcogBase, EBSCOHost, Academic Search Complete, Open J-Gate, SciACCESS.
    Rapid publication: Average time from submission to first decision is 30 days and from acceptance to In Press online publication is 45 days.
    Open Access Journal: Phcog Commn. is an open access journal, which allows authors to fund their article to be open access from publication.

    © 2025 Pharmacognosy Communications. Maintained by Manuscript TechnoMedia LLP.

    Type above and press Enter to search. Press Esc to cancel.

    Scroll Up