Kimber Wise1,2, Harsharn Gill1, Jamie Selby-Pham21School of Science, RMIT University, Bundoora VIC 3083, AUSTRALIA.2Nutrifield, Sunshine West VIC 3020, AUSTRALIA. Pharmacognosy Communications,2019,9,3,85-90.DOI:10.5530/pc.2019.3.18Published:June 2019Type:Original Article ABSTRACT Introduction: The medicinal benefits from inhalation of Cannabis sativa phytochemicals have been extensively reported. Whilst in-silico models are available for prediction of phytochemical pharmacokinetics post-ingestion, no models are available to accurately predict inhalation pharmacokinetics. Therefore, the aim of this study was to explore the relationship between phytochemical physicochemical properties and inhalation pharmacokinetics and to develop an in-silico model for predicting the time of maximal compound concentration in plasma (Tmax) and compound elimination half-life (T½), following inhalation.…
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Rahab W. Kamau1,3,*, Jacob O. Midiwo2, Quintino A. Mgani1, Veronica M. Masila2, Leonidah K. Omosa2, Regina N. Bwire3, Melissa R. Jacob4, Frank T. Wiggers4, Ilias Muhammad4 1Department of Chemistry, College of Natural and Applied Sciences, University of Dar es Salaam, Dar es Salaam, TANZANIA. 2Department of Chemistry, School of Physical Sciences, University of Nairobi, Nairobi, KENYA. 3Department of Chemistry, School of Natural and Applied Sciences, Masinde Muliro University of Science and Technology, Kakamega, KENYA. 4National Centre for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi, USA. Pharmacognosy Communications,2019,9,3,91-95.DOI:10.5530/pc.2019.3.19Published:June 2019Type:Original Article ABSTRACT Introduction: Treatment of…
Ruth Anyango Omole1,2,*, Mainen Julius Moshi1, Matthias Heydenreich3, Hamisi Masanja Malebo4, Jeremiah Waweru Gathirwa5, Richard Owor Oriko6, Leonida Kerubo Omosa6, Jacob Ogweno Midiwo6 1Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, TANZANIA. 2Department of Chemical Science and Technology, Technical University of Kenya, Nairobi, KENYA. 3Institut für Chemie, Universität Potsdam, OT Golm, Haus 25, D/0.19 (Labor E/0.06-0.08), Karl-Liebknecht-Str. 24-25, D-14476 Potsdam, GERMANY. 4Department of Traditional Medicine Research, National Institute for Medical Research, Dar es Salaam, TANZANIA. 5Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI), Nairobi, KENYA. 6Department of Chemistry, University of…
Getmore Chikowe1, Lindi Mpala1, Ian Edwin Cock1,2,* 1School of Environment and Science, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. 2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. Pharmacognosy Communications,,2019,9,3,100-105.DOI:10.5530/pc.2019.3.21Published:June 2019Type:Original Article ABSTRACT Introduction: Closely related plant species often share similar secondary metabolites and bioactivities and are therefore good targets for bioactivity testing when one or more species within a family are known to possess therapeutic properties. The family Lamiaceae has a long history of medicinal usage globally. Many species are known to have therapeutic properties, several species of which have well established…
Lindiwe Mpala1, Getmore Chikowe1, Ian Edwin Cock1,2,* 1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. 2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. Pharmacognosy Communications,2019,9,3,106-111.DOI:10.5530/pc.2019.3.22Published:June 2019Type:Original Article ABSTRACT Introduction: Xanthophyllum fragrans C.T. White is a rainforest tree that is native to north-eastern regions of Australia. X. fragrans leaf extracts were examined for the ability to inhibit the growth of Pseudomonas aeruginosa. Methods: The antimicrobial activity of a methanolic X. fragrans leaf extracts were investigated by disc diffusion and growth time course assays against P. aeruginosa. The growth inhibitory activity was further quantified by MIC determination. Toxicity was determined using…
Ian Edwin Cock1,2,* 1School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. 2Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. Pharmacognosy Communications,2019,9,3,118-120.DOI:10.5530/pc.2019.3.24Published:June 2019Type:The Janus Corner ABSTRACT The neurotoxins (BoNTs) produced by the anaerobic bacterium Clostridium botulinium are amongst the most poisonous proteins known. These toxins block neurotransmitter release by cleaving N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins, inducing paralysis. In a recent study published in Applied and Environmental Microbiology,1 300 natural compounds isolated from a panel of Indian medicinal plants were screened by biochemical and cellular assays for the ability to…
Ian Edwin Cock1,2,* 1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA 2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA Pharmacognosy Communications,2019,9,3,112-117.DOI:10.5530/pc.2019.3.23Published:June 2019Type:Original Article ABSTRACT Introduction: The development of multi-antibiotic resistant strains of bacteria has necessitated the search for new effective antibacterial therapies. Several Grevillea spp. were used traditionally to treat pathogenic illness and are rich in phytocompounds with antibacterial activity. Despite this, the antibacterial activity of Australian Grevillea spp. extracts have not been extensively examined. Methods: The ability of G. juncifolia and G. robusta leaf and flower extracts to inhibit the growth of gram-negative and gram-positive bacterial species and some…
Ian Edwin Cock1,2,* 1Environmental Futures Research Institute, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. 2School of Natural Sciences, Nathan Campus, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. Pharmacognosy Communications,2019,9,3,121.Published:June 2019Type:Medicinal Plant Images ABSTRACT Australian Acacia spp. The genus Acacia (family Fabaceae) is a large genus of more than 1200 trees and shrubs which are widely distributed throughout the world, with more than 700 species indigenous to Australia. The Australian species had multiple medicinal uses by indigenous Australians, including being used to treat diarrhoea and hyperglycemia1 and as a general antiseptic agent.2-5 Many Australian Acacia species have been…
Pharmacognosy Communications,2019,9,3,122.Published:June 2019Type:Upcoming Events Download PDF
Getmore Chikowe1, Lindiwe Mpala1, Ian Edwin Cock1,2 1School of Environment and Science, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA. 2Environmental Futures Research Institute, Griffith University, 170 Kessels Rd, Nathan, Brisbane, Queensland, AUSTRALIA Pharmacognosy Communications,2019,9,2,39-46.DOI:10.5530/pc.2019.2.10Published: April 2019Type: Original Article ABSTRACT Introduction: The development of multi-antibiotic resistant strains of bacteria has necessitated the search for new effective antibacterial therapies. Many Callistemon spp. were used traditionally to treat pathogenic illness and are rich in terpenoids with reported antibacterial activity. Despite this, the antibacterial activity of C. linearis leaf extracts has not been extensively examined. Methods: The ability of C. linearis leaf extracts to inhibit the growth of gram-negative and gram-positive…